Organic methodology development
HAN-YONG BAE received his B.Sc. (2010), M.Sc. (2012) and Ph.D. (2015) degrees from SUNGKYUNKWAN UNIVERSITY (Korea) conducting studies on Brønsted base catalyzed asymmetric syntheses. During his graduate studies, Han-Yong developed polyketide biosynthesis mimic catalytic reactions, and discovered hydrophobic amplification effect in water promoted asymmetric catalysis. He then moved to Germany and pursued postdoctoral research at MAX-PLANCK-INSTITUT FÜR KOHLENFORSCHUNG (2015–2019). He developed new highly active catalysts for extremely challenging Lewis acid-catalyzed asymmetric reactions (parts-per-billion-level organocatalysis). In February 2019, he was appointed as an Assistant Professor in the Department of Chemistry at the UNIST, Korea.
The Organic Reaction Design & Catalysis (ORDC) Lab is a young and active organic chemistry research group. Our research interests mainly span from the invention of new innovative catalytic organic transformations to the design of novel catalysts, to uncover previously unexplored pathways. The primary direction pursued in our research group is, to exploit fundamental homogeneous catalysis as a tool for further multidisciplinary and practical applications in the synthesis of complex biologically relevant molecules, materials science, and biological science.
촉매유기반응 연구실 (ORDC)은 젊고 열정적인 유기합성 연구 그룹입니다. 관심 연구분야로, 촉매를 활용한 새롭고 매력적인 유기반응의 발명에서부터, 이전에 전혀 보고되지 않은 새로운 촉매의 설계와 개발을 포함하고 있습니다. 우리 그룹에서 추구하는 주요 연구방향은 균일계 촉매반응의 연구 및 개발을 기초로 하여, 이를 토대로 나아가 생리활성이 있는 복잡한 유기분자의 합성, 재료과학 및 생명과학에의 응용을 목표로 하고 있습니다.
Approaching sub-ppm level asymmetric organocatalysis of a highly challenging and scalable carbon–carbon bond forming reaction
H. Y. Bae, D. Höfler, P. S. J. Kaib, P. Kasaplar, C. K. De, A. Döhring, S. Lee, K. Kaupmees, I. Leito, B. List* Nature Chemistry 2018
, 10, 888.
Asymmetric counteranion-directed Lewis acid organocatalytsis for scalable cyanosilylation of aldehydes
Z. Zhang, H. Y. Bae, J. Guin, C. Rabalakos, M. v.Gemmeren, M. Leutzsch, M. Klussmann, B. List* Nature Communications, 2016
Direct catalytic asymmetric Mannich reaction with dithiomalonate as an excellent donor: the first organocatalytic synthesis of (R)-Sitagliptin
H. Y. Bae, M. J. Kim, J. H. Sim, C. E. Song* Angew. Chem. Int. Ed., 2016
, 55, 10825.
Organocatalytic enantioselective decarboxylative aldol reaction of malonic acid half thioesters to aldehydes
H. Y. Bae, J. H. Sim, J. W. Lee, B. List,* C. E. Song* Angew. Chem. Int. Ed., 2013
, 52, 12143.