Lim, Mi Hee

Lim, Mi Hee

Lim, Mi Hee 임미희
Associate Professor
Bioinorganic Chemistry
Chemical Biology

Research Summary
The research interests of the Lim lab lie in the broad field of bioinorganic chemistry as it interfaces with chemical biology, biochemistry, medicinal chemistry, and neuroscience. Our research objectives are to (a) identify the etiologies of human neurodegenerative disorders [particularly, elucidation of the roles of metals, proteins, and reactive oxygen species (ROS) individually or mutually in human neurodegenerative diseases]; (b) discover new, effective therapeutics for these diseases. These goals can be accomplished through designing small molecule-based or protein-based reagents (i) as chemical tools through understanding of the complicated networks between metals, various proteins and/or other molecules (i.e., neurotransmitters); (ii) as multi-tasking therapeutics. Students in our group have engaged in synthetic chemistry (organic and inorganic syntheses), physical methods (NMR, EPR, IR, CD, and UV-vis spectroscopy, mass spectrometry, and X-ray crystallography), as well as biological techniques (biological assays and mammalian cell culture/analysis).

임미희 교수의 실험실은 화학생물학, 생화학, 의약 화학, 신경 과학에 걸쳐 있는 넓은 분야에서의 생무기화학에 연구 관심사를 두고 있습니다. 이 실험실의 연구 목적은 (a) 인간 신경병성 질병의 원인(질병 내에서의 금속 이온, 단백질, 활성 산소의 개개인 또는 상호적인 역할)을 찾고, (b) 이러한 질병들에 대한 효과적인 치료법을 새롭게 개발하는 것입니다. 이 목표들은 저분자 또는 단백질에 기반을 둔 디자인한 화학도구를 도입하여 성공시키고자 합니다. 이들은 (i) 메탈과 여러 단백질, 혹은 신경 전달 물질과 같은 분자들 사이의 네트워크를 이해하는 데에 쓰일 수 있으며, (ii) 그 자체로 다기능을 가진 치료법에 적용될 수 있습니다. 임미희 교수 연구실의 학생들은 합성 화학(유기/무기 합성), 물리적 방법(NMR, EPR, IR, CD, UV-Vis 분광학, 질량 분석법, X-ray 결정학) 뿐만
아니라 생물학적 기법(생물 검정, 세포 배양/분석)에도 참여하고 있습니다.

Representative Publications
Jeffrey S. Derrick, Richard A. Kerr, Younwoo Nam, Shin Bi Oh, Hyuck Jin Lee, Kaylin G. Earnest, Nayoung Suh, Kristy L. Peck, Mehmet Ozbil, Kyle J. Korshavn, Ayyalusamy Ramamoorthy, Rajeev Prabhakar, Edward J. Merino, Jason Shearer,* Joo-Yong Lee,* Brandon T. Ruotolo,* Mi Hee Lim*J. Am. Chem. Soc. 2015, 137(46), 14785-14797.
“A Redox-Active, Compact Molecule for the Crosslinking of Amyloidogenice Peptides into Nontoxic, Off-pathway Aggregates: In Vitro and In Vivo Efficacy and Molecular Mechanisms”

Michael W. Beck, Shin Bi Oh, Richard A. Kerr, Hyuck Jin Lee, So He Kim, Sujeoung Kim, Milim Jang, Brandon T. Ruotolo,* Joo-Yong Lee* and Mi Hee Lim* Chem. Sci. 2015, 6(3), 1879-1886.
“A Rationally Designed Small Molecule for Identify an In Vivo Link of Metal-Amyloid- complexes to the Pathogenesis of Alzheimer’s Disease”

Masha G. Savelieff, Alaina S. DeToma, Jeffrey S. Derrick, and Mi Hee Lim*, Acc. Chem. Res. 2014, 47(8), 2475-2482.
"The Ongoing Search for Small Molecules to Study Metal-Associated Amyloid-β Species in Alzheimer’s Disease"

Hyuck Jin Lee, Kyle J. Korshavn, Akiko Kochi, Jeffrey S. Derrick, Mi Hee Lim* Chem. Soc. Rev. 2014, 43(19), 6672-6682.
“Cholesterol and Metal Ions in Alzheimer’s Disease”

Sanghyun Lee, Xueyun Zheng, Janarthanan Krishnamoorthy, Hyun Min Park, Jeffrey R. Brender, Masha G. Savelieff, Jin Hoon Kim, Jeffrey S. Derrick, Akiko Kochi, Hyuck Jin Lee, Cheal Kim, Ayyalusamy Ramamoorthy*, Michael T. Bowers*, Mi Hee Lim* J. Am. Chem. Soc. 2014, 136(1), 299-310.
“Rational Design of a Structural Framework with Potential Use to Develop Chemical Reagents That Target and Modulate Multiple Facets of Alzheimer’s Disease”

Suk-Joon Hyung, Alaina S. DeToma, Jeffrey R. Brender, Sanghyun Lee, Subramanian Vivekanandan, Akiko Kochi, Ayyalusamy Ramamoorthy*, Brandon T. Ruotolo*, Mi Hee Lim* Proc. Natl. Acad. Sci. U.S.A. 2013, 110(10), 3743-3748.
“Insights into the Antiamyloidogenic Properties of the Green Tea Extract (−)-Epigallocatechin-3-gallate toward Metal-associated Amyloid-β Species”

Jung-Suk Choi,§ Joseph J. Braymer,§ Ravi P. R. Nanga, Ayyalusamy Ramamoorthy, Mi Hee Lim* Proc. Natl. Acad. Sci. U.S.A. 2010, 107(51), 21990-21995.
“Design of Small Molecules That Target Metal-Aβ Species and Regulate Metal-Induced Aβ Aggregation and Neurotoxicity”