Duyoung Min is an assistant professor at UNIST Chemistry since 2019, studying membrane protein science and single-molecule science. His long-term vision is to discover hidden chemistry and physics of biomolecules and their interactions with diverse single-molecule approaches. Before joining UNIST, as a postdoctoral scholar at UCLA Chemistry & Biochemistry, he studied a biophysical chemistry behind the unique fold of a chloride transporter, how the complex membrane protein possibly folds. Before that, as a doctoral student at KAIST Physics, he developed precision force techniques to understand SNARE zipping mechanism at single-molecule level. During the postdoctoral and doctoral periods, he also developed a new approach of the magnetic tweezers platform to tackle the notorious membrane protein folding problem. Before entering the research career, he was a little Electronics undergraduate, exploring the basic principles of science and engineering through textbooks, pondering over what life is from time to time.
Duyoung Min laboratory conducts interdisciplinary researches potentially contributing to disease treatment by exploiting single-molecule methods. Especially, the main research directions are to understand misfolding disease mechanisms of membrane proteins, and to develop unique single-molecule techniques tackling their underlying biophysical chemistry. Membrane proteins are the major drug target accounting for ~40% of drugs, so they are medically very important protein class. However, their scientific progress is relatively sluggish due to many technical challenges. The vision of our laboratory is, by overcoming the challenges, to better understand the fundamental membrane protein science and to develop practical methodologies applicable to medicine.
민두영 교수 연구실에서는 단분자 기술을 이용하여 궁극적으로 질병치료에 기여할 수 있는 연구를 수행합니다. 특별히 생체막 단백질(이하, 막단백질)의 잘못접힘 현상으로 인한 질병 기작 연구와 막단백질에 관한 중요한 생물리화학적 메커니즘을 이해하는 다양한 단분자 기법의 개발이 주요 연구 방향입니다. 막단백질은 약물의 약 40%가 타겟으로 할 정도로 의학적으로 매우 중요한 단백질 군에 속합니다. 하지만 여러 기술적인 어려움으로 인해 연구의 진전이 상대적으로 미미한 수준에 머물고 있습니다. 본 연구실은 이러한 어려움을 극복하여 막단백질 과학의 근본적인 이해와 의학적으로 적용가능한 방법론 개발을 연구실의 비전으로 삼고 있습니다.
Watching helical membrane proteins fold reveals a common N- to C-terminal folding pathway
Choi, H.-K.*, Min, D.* et al., Science, 2019
, 366, 1150.
Unfolding of a ClC chloride transporter retains memory of its evolutionary history
Min, D. et al., Nature Chemical Biology, 2018
, 14, 489.
Accurate computational design of multipass transmembrane proteins
Lu, P., Min, D. et al., Science, 2018
, 359, 1042.
Mapping the energy landscape for second-stage folding of a single membrane protein
Min, D. et al., Nature Chemical Biology, 2015
, 11, 981.
Spring-loaded unraveling of a single SNARE complex by NSF in one round of ATP turnover
Ryu, J.K.*, Min, D.* et al., Science, 2015
, 347, 1485.
Mechanical unzipping and rezipping of a single SNARE complex reveals hysteresis as a force-generating mechanism
Min, D. et al., Nature Communications, 2013
, 4, 1705.