The research theme of the Ryu research group is the development of new disease therapy using supramolecular approach (Supramolecular Therapeutics). The Ryu group have developed the conventional-drug-free approach for a new anti-cancer/anti-ageing therapy, that intracellular (supramolecular) polymerization inside the mitochondria induced the dysfunction of mitochondria by disrupting the membrane, resulting in the selective apoptosis of cancer/senescent cells. In addition, the Ryu group have developed a facile synthetic method for highly stable, polymer/protein-modified hollow nanoparticles using a non-covalent approach to enhance in vivo efficacy and target ability to caner and senescent cells.